Prewords: Vibrio vulnificus infection is rare and emergent. Life and limb threatening are always impressed. Life salvage or limb salvage is very critical. Traditional treatments including early recognition, intravenous antibiotics, and aggressive debridement leaded to high percentage of motality or limb loss still. Hyperbaric oxygen therapy was added as an adjuvant therapy in order to improve the outcome. There were only 2 published papers in the literature. (one in English, another in Japanese)

Materials and Methods: From Sep 2006 to Apr 2008, 2 patients infected by Vibrio vulnificus were treated by early recognition, intravenous antibiotics, aggressive debridement, and adjuvant hyperbaric oxygen. They are both liver cirrhosis patients. The first 62 years old male patient (no. 1) with right index tip Vibrio vulnificus infection accepted 1 session hyperbaric oxygen therapy in acute stage. The second 72 years old female (no. 2) with left leg Vibrio vulnificus infection accepted 34 sessions hyperbaric oxygen therapy. They were confirmed by wound culture (no. 1) and blood culture (no. 2) later.

Results: The number 1 patient was recovered with only loss of distal phalanx of index. He was admitted with only 8 days. The number 2 patient was recovered with 3 sessions split thickness skin graft assisted with hyperbaric oxygen therapy. The left leg was preserved finally.